Role of Noni in Diabetes
ROLE OF NONI IN DIABETES
Diabetes is a disease in which the body does not produce or properly use insulin. Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life.
Diabetes is a disease in which the body does not produce or properly use insulin. Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life.
Major Types of Diabetes mellitus
Diabetes is classified into two types:
Type 1. Insulin Dependent Diabetes Mellitus (IDDM): It is also called as type I diabetes.
Type 2. Non-Insulin Dependent Diabetes Mellitus (NIDDM): It is also called as type II diabetes.
Type 1 diabetes mellitus results from the body's failure to produce insulin, the hormone that "unlocks" the cells of the body, allowing glucose to enter and fuel them. Type 1 diabetes is usually diagnosed in children and young adults, and was previously known as juvenile diabetes. In type 1 diabetes, the body does not produce insulin.
Type 2 diabetes mellitus results from insulin resistance (a condition in which the body fails to properly use insulin), combined with relative insulin deficiency. Type 2 diabetes is the most common form of diabetes. In type 2 diabetes, either the body does not produce enough insulin or the cells ignore the insulin.
For all types of diabetes, the metabolism of carbohydrates (including sugars such as glucose), proteins, and fats is altered
Diabetes is classified into two types:
Type 1. Insulin Dependent Diabetes Mellitus (IDDM): It is also called as type I diabetes.
Type 2. Non-Insulin Dependent Diabetes Mellitus (NIDDM): It is also called as type II diabetes.
Type 1 diabetes mellitus results from the body's failure to produce insulin, the hormone that "unlocks" the cells of the body, allowing glucose to enter and fuel them. Type 1 diabetes is usually diagnosed in children and young adults, and was previously known as juvenile diabetes. In type 1 diabetes, the body does not produce insulin.
Type 2 diabetes mellitus results from insulin resistance (a condition in which the body fails to properly use insulin), combined with relative insulin deficiency. Type 2 diabetes is the most common form of diabetes. In type 2 diabetes, either the body does not produce enough insulin or the cells ignore the insulin.
For all types of diabetes, the metabolism of carbohydrates (including sugars such as glucose), proteins, and fats is altered
Cause of diabetes
In Type 1 diabetes the cells in the pancreas that make insulin are destroyed, causing a severe lack of insulin. This is thought to be the result of the body attacking and destroying its own cells in the pancreas - known as an autoimmune reaction.
It's not clear why this happens, but a number of explanations and possible triggers of this reaction have been proposed.
These include:
infection with a specific virus or bacteria;
exposure to food-borne chemical toxins; and
exposure as a very young infant to cow's milk, where an as yet unidentified component of this triggers the autoimmune reaction in the body.
However, these are only hypotheses and are by no means proven causes.
Type 2 diabetes is believed to develop when the receptors on cells in the body that normally respond to the action of insulin fail to be stimulated by it - this is known as insulin resistance. In response to this more insulin may be produced, and this over-production exhausts the insulin-manufacturing cells in the pancreas; there is simply insufficient insulin available; and the insulin that is available may be abnormal and therefore doesn't work properly.
The following risk factors increase the chances of someone developing Type 2 diabetes:
Increasing age;
obesity; and
physical inactivity.
Rarer causes of diabetes include:
Certain medicines;
pregnancy (gestational diabetes); and
any illness or disease that damages the pancreas and affects its ability to produce insulin e.g. pancreatitis.
In Type 1 diabetes the cells in the pancreas that make insulin are destroyed, causing a severe lack of insulin. This is thought to be the result of the body attacking and destroying its own cells in the pancreas - known as an autoimmune reaction.It's not clear why this happens, but a number of explanations and possible triggers of this reaction have been proposed.
These include:
infection with a specific virus or bacteria;
exposure to food-borne chemical toxins; and
exposure as a very young infant to cow's milk, where an as yet unidentified component of this triggers the autoimmune reaction in the body.
However, these are only hypotheses and are by no means proven causes.
Type 2 diabetes is believed to develop when the receptors on cells in the body that normally respond to the action of insulin fail to be stimulated by it - this is known as insulin resistance. In response to this more insulin may be produced, and this over-production exhausts the insulin-manufacturing cells in the pancreas; there is simply insufficient insulin available; and the insulin that is available may be abnormal and therefore doesn't work properly.The following risk factors increase the chances of someone developing Type 2 diabetes:
Increasing age;
obesity; and
physical inactivity.
Rarer causes of diabetes include:
Certain medicines;
pregnancy (gestational diabetes); and
any illness or disease that damages the pancreas and affects its ability to produce insulin e.g. pancreatitis.
What doesn't cause diabetes
Eating sweets or the wrong kind of food does not cause diabetes. However, it may cause obesity and this is associated with people developing Type 2 diabetes. Diabetes is not contagious. Someone with diabetes cannot pass it on to anyone else.
Symptoms of Diabetes
Increased thirst (Polydipsia)
Increased urination (Polyuria)
Increased appetite (Polyphagia)
Weight loss despite increased appetite
Nausea
Abdominal pain
Fatigue (severe weak ness)
Absence of menstruation
Blurred vision
Frequent or slow-healing infections
Erectile dysfunction
Itching of skin
Complications of Diabetes are:Immediate complications: Diabetic Ketoacidosis (DKA) and coma. It is an important and serious complication which occurs especially in IDDM.
Late complications are Myocardial infarction and stroke:
They occur due to atherosclerotic changes in cerebral and coronary blood vessels
Diabetic retinopathy which may lead to irreversible blindness.
Diabetic cataract due to damage and changes in lens protein.
Diabetic retinopathy due to damage of the kidney. It is characterized by proteinuria, hypertension and oedema.
Peripheral neuritis manifesting as loss of sensation and tingling.
Diabetic gangrene caused by atherosclerotic changes of blood vessels, which lead to decreased blood supply.
Skin lesions such as boils, ulcers and carbuncles. Ulcers of foot are very common which should be taken care of. Otherwise it may progress to loss of limb.
Pulmonary tuberculosis: Diabetic patients are susceptible to pulmonary
Eating sweets or the wrong kind of food does not cause diabetes. However, it may cause obesity and this is associated with people developing Type 2 diabetes. Diabetes is not contagious. Someone with diabetes cannot pass it on to anyone else.
Symptoms of Diabetes
Increased thirst (Polydipsia)
Increased urination (Polyuria)
Increased appetite (Polyphagia)
Weight loss despite increased appetite
Nausea
Abdominal pain
Fatigue (severe weak ness)
Absence of menstruation
Blurred vision
Frequent or slow-healing infections
Erectile dysfunction
Itching of skin
Complications of Diabetes are:Immediate complications: Diabetic Ketoacidosis (DKA) and coma. It is an important and serious complication which occurs especially in IDDM.
Late complications are Myocardial infarction and stroke:
They occur due to atherosclerotic changes in cerebral and coronary blood vessels
Diabetic retinopathy which may lead to irreversible blindness.
Diabetic cataract due to damage and changes in lens protein.
Diabetic retinopathy due to damage of the kidney. It is characterized by proteinuria, hypertension and oedema.
Peripheral neuritis manifesting as loss of sensation and tingling.
Diabetic gangrene caused by atherosclerotic changes of blood vessels, which lead to decreased blood supply.
Skin lesions such as boils, ulcers and carbuncles. Ulcers of foot are very common which should be taken care of. Otherwise it may progress to loss of limb.
Pulmonary tuberculosis: Diabetic patients are susceptible to pulmonary
General management and Treatment of diabetes included as
Diet and weight control
Meal planning includes choosing healthy foods, eating the right amount of food, and eating meals at the right time. You should work closely with your health care provider to learn how much fat, protein, and carbohydrates you need in your diet. Your specific meal plans need to be tailored to your food habits and preferences.
Managing your weight and eating a well-balanced diet are important. Some people with type 2 diabetes can stop medications after intentional weight loss, although the diabetes is still present.
Regular physical activity
Regular exercise is important for everyone, but especially if you have diabetes. Regular exercise helps control the amount of glucose in the blood. It also helps burn excess calories and fat so you can manage your weight. Exercise improves overall health by improving blood flow and blood pressure. It decreases insulin resistance even without weight loss. Exercise also increases the body's energy level, lowers tension, and improves your ability to handle stress
Education:The diabetic patient needs to be educated about change in life-style, diet, exercise and drugs. He should be taught how to monitor blood and urine glucose
Medication
When diet and exercise do not help maintain normal or near-normal blood glucose levels your doctor may prescribe medication
InsulinOral ant diabetic drugs
Diet and weight control
Meal planning includes choosing healthy foods, eating the right amount of food, and eating meals at the right time. You should work closely with your health care provider to learn how much fat, protein, and carbohydrates you need in your diet. Your specific meal plans need to be tailored to your food habits and preferences.Managing your weight and eating a well-balanced diet are important. Some people with type 2 diabetes can stop medications after intentional weight loss, although the diabetes is still present.
Regular physical activity
Regular exercise is important for everyone, but especially if you have diabetes. Regular exercise helps control the amount of glucose in the blood. It also helps burn excess calories and fat so you can manage your weight. Exercise improves overall health by improving blood flow and blood pressure. It decreases insulin resistance even without weight loss. Exercise also increases the body's energy level, lowers tension, and improves your ability to handle stressEducation:The diabetic patient needs to be educated about change in life-style, diet, exercise and drugs. He should be taught how to monitor blood and urine glucose
Medication
When diet and exercise do not help maintain normal or near-normal blood glucose levels your doctor may prescribe medication
InsulinOral ant diabetic drugs
ROLE OF NONI
For thousands of years Morinda citrifolia, a fruit bearing plant commonly known as Noni, has been used in an effort to battle a wide array of health challenges. In recent years, the health-enhancing properties of this plant have been harnessed and made available for the benefit of people.
This miracle from paradise has been described as one of the most important health discoveries of the twentieth century. Noni has earned this praise through its powerful ability to help with a variety of health conditions and act as a natural immune system booster.
Thousands of people worldwide have attributed improvements in their health to the tremendous and often life-saving benefits found in Noni. Recent scientific research in both clinical and laboratory settings validate the efficacy of this ancient fruit. In addition, doctors and health care professionals around the world are praising Noni as their patients win battles against chronic conditions many have suffered from for years.
The role of immune system in diabetesResearch has shown that if the immune system starts to turn on itself - perhaps the result of an autoimmune disorder - it may cause a complete obliteration of the pancreas’ beta cells or at least a reduction in the number of functioning beta cells. This then affects the amount and purity and effectiveness of the body’s insulin. However, if the immune system is able to ward off an attack, the integrity of the body’s insulin will be maintained.
More refined tests now make it possible to detect faulty immune antibodies in the blood well in advance of a person showing symptoms of diabetes. In some adults, these destructive antibodies may be present years before diabetic symptoms appear. This lag time is known as the “prediabetic stage.”
Noni controls diabetesOne such health challenge that many have found Noni to help with is diabetes. Doctors and researchers suggest that Noni has the ability to help strengthen the immune system which, in turn, can help the body maintain strong insulin levels. As a result, many Type I and II diabetics have finally found relief from this often deadly disease in the form of Noni.
Many of the effects of diabetes can be controlled. While there is no cure for the disease, studies show that by keeping one’s blood sugar as close to normal as possible significantly reduces diabetes’ long-term complications.
What way Noni HELP IN DIABETES
The miracle of Xeronine - Xeronine, the alkaloid of Noni in the presence of insulin activate the peripheral cell membrane insulin receptors and helps for the normal intracellular absorption of glucose as well as corrects the intracellular post receptor defect of the action of insulin for carbohydrate metabolism and thus prevents the insulin resistance condition in diabetes cases.
Noni the cell-rejuvenator - Noni is believed to fortify and maintain the cell structure; this can be accomplished by Noni acting as an adaptogen that can aid “sick” cells in repairing themselves. Xeronine and other nutraceuticals present in Noni may convert the abnormal inactive insulin molecule present in type 2 diabetes mellitus to an active form by modifying its cell rigidity and functional level to maintain its normal function of carbohydrate metabolism in our body.
For thousands of years Morinda citrifolia, a fruit bearing plant commonly known as Noni, has been used in an effort to battle a wide array of health challenges. In recent years, the health-enhancing properties of this plant have been harnessed and made available for the benefit of people.
This miracle from paradise has been described as one of the most important health discoveries of the twentieth century. Noni has earned this praise through its powerful ability to help with a variety of health conditions and act as a natural immune system booster.
Thousands of people worldwide have attributed improvements in their health to the tremendous and often life-saving benefits found in Noni. Recent scientific research in both clinical and laboratory settings validate the efficacy of this ancient fruit. In addition, doctors and health care professionals around the world are praising Noni as their patients win battles against chronic conditions many have suffered from for years.
The role of immune system in diabetesResearch has shown that if the immune system starts to turn on itself - perhaps the result of an autoimmune disorder - it may cause a complete obliteration of the pancreas’ beta cells or at least a reduction in the number of functioning beta cells. This then affects the amount and purity and effectiveness of the body’s insulin. However, if the immune system is able to ward off an attack, the integrity of the body’s insulin will be maintained.
More refined tests now make it possible to detect faulty immune antibodies in the blood well in advance of a person showing symptoms of diabetes. In some adults, these destructive antibodies may be present years before diabetic symptoms appear. This lag time is known as the “prediabetic stage.”
Noni controls diabetesOne such health challenge that many have found Noni to help with is diabetes. Doctors and researchers suggest that Noni has the ability to help strengthen the immune system which, in turn, can help the body maintain strong insulin levels. As a result, many Type I and II diabetics have finally found relief from this often deadly disease in the form of Noni.
Many of the effects of diabetes can be controlled. While there is no cure for the disease, studies show that by keeping one’s blood sugar as close to normal as possible significantly reduces diabetes’ long-term complications.
What way Noni HELP IN DIABETES
The miracle of Xeronine - Xeronine, the alkaloid of Noni in the presence of insulin activate the peripheral cell membrane insulin receptors and helps for the normal intracellular absorption of glucose as well as corrects the intracellular post receptor defect of the action of insulin for carbohydrate metabolism and thus prevents the insulin resistance condition in diabetes cases.
Noni the cell-rejuvenator - Noni is believed to fortify and maintain the cell structure; this can be accomplished by Noni acting as an adaptogen that can aid “sick” cells in repairing themselves. Xeronine and other nutraceuticals present in Noni may convert the abnormal inactive insulin molecule present in type 2 diabetes mellitus to an active form by modifying its cell rigidity and functional level to maintain its normal function of carbohydrate metabolism in our body.
Noni works as a ‘Healthy, Immune System Promoter - One of the Noni’s effects is on the pancreas and immune system. Current studies have revealed that Noni may help promote a healthy immune system or by either enhancing an already functioning system or by stimulating a sluggish one. Noni activating our body immune system may improve the non functioning beta cells of the pancreas to an active form to produce the normal insulin from the beta cells and also maintain a normal insulin level in the blood to the response of the carbohydrate diet.
Low Glycemic Index – A 3:1 ratio of carbohydrates to fiber in Noni juice helps balance blood glucose level. Glycemic index refers to a method of classification by which a number is assigned to foods based on how they affect blood sugar levels. Foods that contain the same amount of total carbohydrate may have a different glycemic index. For example kidney beans increase blood sugar levels more significantly than Soya beans, because of its higher glycemic value. Noni has a very low glycemic index and hence it reduces the risk of chronic conditions of diabetics
Noni might have the role by modifying our body immune system keeps the sensitivity of beta cells of the pancreas intact to produce an adequate amount of insulin in response to elevated blood glucose level by keeping and maintaining the balance of release of the neuro-endocrine signals of the brain.
Noni may help the diabetic complications like care of diabetic gangrene by its powerful healing effects and also helps diabetic poly neuropathy symptoms by providing number essential micronutrients, vitamins, essential minerals and amino acids that it contains.
Noni may also help relieve diabetic complications through its ability to stimulate the body’s production of nitric oxide. Nitric oxide and Scopoletin one ingredient in noni helps also reduce the diabetic hypertension. Both may also be important factors in decreasing symptoms such as poor circulation and vision problems.
Low Glycemic Index – A 3:1 ratio of carbohydrates to fiber in Noni juice helps balance blood glucose level. Glycemic index refers to a method of classification by which a number is assigned to foods based on how they affect blood sugar levels. Foods that contain the same amount of total carbohydrate may have a different glycemic index. For example kidney beans increase blood sugar levels more significantly than Soya beans, because of its higher glycemic value. Noni has a very low glycemic index and hence it reduces the risk of chronic conditions of diabetics
Noni might have the role by modifying our body immune system keeps the sensitivity of beta cells of the pancreas intact to produce an adequate amount of insulin in response to elevated blood glucose level by keeping and maintaining the balance of release of the neuro-endocrine signals of the brain.
Noni may help the diabetic complications like care of diabetic gangrene by its powerful healing effects and also helps diabetic poly neuropathy symptoms by providing number essential micronutrients, vitamins, essential minerals and amino acids that it contains.
Noni may also help relieve diabetic complications through its ability to stimulate the body’s production of nitric oxide. Nitric oxide and Scopoletin one ingredient in noni helps also reduce the diabetic hypertension. Both may also be important factors in decreasing symptoms such as poor circulation and vision problems.
Diabetic Foot Ulcer
ROLE OF NONI IN DIABETIC FOOT ULCER
Diabetics are prone to foot ulcerations due to both neurologic and vascular complications. Peripheral neuropathy can cause altered or complete loss of sensation in the foot or leg. The diabetic with advanced neuropathy looses all sharp-dull discrimination. Any cuts or trauma to the foot can go completely unnoticed for days or weeks in a patient with neuropathy. It's not uncommon to have a patient with neuropathy tell you that the ulcer "just appeared" when, in fact, the ulcer has been present for quite some time. The charcot foot deformity occurs as a result of decreased sensation. People with "normal" feeling in their feet automatically determine when too much pressure is being placed on an area of the foot. Once identified, our bodies instinctively shift position to relieve this stress. A patient with advanced neuropathy looses this important mechanism. As a result, tissue ischemia and necrosis may occur leading to plantar ulcerations. Microfractures in the bones of the foot go unnoticed and untreated, resulting in disfigurement, chronic swelling and additional bony prominences.
The most frequent underlying etiologies of diabetes foot ulcers are neuropathy, trauma, deformity, high plantar pressures, and peripheral arterial disease. Other factors in ulceration are ischemia, callus formation, and edema. Although infection is rarely implicated in the etiology of diabetic foot ulcers, the ulcers are susceptible to infection once the wound is present. Many of the risk factors for foot ulcer are also predisposing factors for amputation, because ulcers are primary causes leading to amputation.
Noni in Diabetic Foot Ulcer
Noni is rich with amino acids. Xeronine, the alkaloid of Noni enhances the enzyme activity and protein structure. Therefore it helps for tissue repairing and wound healing associated with diabetic gangrene.
Noni stimulates the body’s production of nitric oxide, a chemical which allows the blood vessels to dilate more easily and be more elastic. In other words it acts as a vaso dilator. The foot ulcer due to peripheral ischaemic condition can be controlled by Noni as it stimulates the body’s production of nitric oxide that act like a vaso dilator. White blood cells in the body use nitric oxide to kill infectious agents such as bacteria, fungi and parasites. Hence nitric oxide present in Noni also helps to prevent infection in case diabetes foot sores.
Scopoletin present in Noni have a wide potential action. It acts like a vasodilator as well as having anti-inflammatory, anti-bacterial, and anti-fungal properties and thus helps in healing of the foot ulcers.
Acubin, L-asperuloside, and alizarin in the Noni fruit, as well as some other anthraquinone compounds in Noni, are all proven antibacterial agents. These compounds have been shown to fight against infectious bacteria strains such as, Staphylococcus aureus, Streptococcus, Pseudomonas aeruginosa, Baciillis subtilis, Escherichia coli, Salmonella, and Shigela etc. These antibacterial elements within Noni help to control of the infections associated with diabetes ulcer.
Diabetics are prone to foot ulcerations due to both neurologic and vascular complications. Peripheral neuropathy can cause altered or complete loss of sensation in the foot or leg. The diabetic with advanced neuropathy looses all sharp-dull discrimination. Any cuts or trauma to the foot can go completely unnoticed for days or weeks in a patient with neuropathy. It's not uncommon to have a patient with neuropathy tell you that the ulcer "just appeared" when, in fact, the ulcer has been present for quite some time. The charcot foot deformity occurs as a result of decreased sensation. People with "normal" feeling in their feet automatically determine when too much pressure is being placed on an area of the foot. Once identified, our bodies instinctively shift position to relieve this stress. A patient with advanced neuropathy looses this important mechanism. As a result, tissue ischemia and necrosis may occur leading to plantar ulcerations. Microfractures in the bones of the foot go unnoticed and untreated, resulting in disfigurement, chronic swelling and additional bony prominences.
The most frequent underlying etiologies of diabetes foot ulcers are neuropathy, trauma, deformity, high plantar pressures, and peripheral arterial disease. Other factors in ulceration are ischemia, callus formation, and edema. Although infection is rarely implicated in the etiology of diabetic foot ulcers, the ulcers are susceptible to infection once the wound is present. Many of the risk factors for foot ulcer are also predisposing factors for amputation, because ulcers are primary causes leading to amputation.Noni in Diabetic Foot Ulcer
Noni is rich with amino acids. Xeronine, the alkaloid of Noni enhances the enzyme activity and protein structure. Therefore it helps for tissue repairing and wound healing associated with diabetic gangrene.
Noni stimulates the body’s production of nitric oxide, a chemical which allows the blood vessels to dilate more easily and be more elastic. In other words it acts as a vaso dilator. The foot ulcer due to peripheral ischaemic condition can be controlled by Noni as it stimulates the body’s production of nitric oxide that act like a vaso dilator. White blood cells in the body use nitric oxide to kill infectious agents such as bacteria, fungi and parasites. Hence nitric oxide present in Noni also helps to prevent infection in case diabetes foot sores.
Scopoletin present in Noni have a wide potential action. It acts like a vasodilator as well as having anti-inflammatory, anti-bacterial, and anti-fungal properties and thus helps in healing of the foot ulcers.
Acubin, L-asperuloside, and alizarin in the Noni fruit, as well as some other anthraquinone compounds in Noni, are all proven antibacterial agents. These compounds have been shown to fight against infectious bacteria strains such as, Staphylococcus aureus, Streptococcus, Pseudomonas aeruginosa, Baciillis subtilis, Escherichia coli, Salmonella, and Shigela etc. These antibacterial elements within Noni help to control of the infections associated with diabetes ulcer.
Noni controls diabetes –
Xeronine, the alkaloid of Noni in the presence of insulin activate the peripheral cell membrane insulin receptors and helps for the normal intracellular absorption of glucose as well as corrects the intracellular post receptor defect of the action of insulin for carbohydrate metabolism and thus prevents the insulin resistance condition in Type – II Diabetes Mellitus condition.
Noni works as a ‘Healthy, Immune System Promoter –
Current studies have revealed that Noni may help promote a healthy immune system either by enhancing an already functioning system or by stimulating a sluggish one. Noni activating our body immune system may improve the non functioning beta cells of the pancreas to an active form to produce the normal insulin from the beta cells and also maintain a normal insulin level in the blood to the response of the carbohydrate diet.
Low Glycemic Index –
A 3:1 ratio of carbohydrates to fiber in Noni juice helps balance blood glucose level. With the treatment of diabetic foot ulcer the blood sugar should be within the normal range.
The body immunity power also has a major role in the healing process of diabetes foot ulcer. Noni boosts the body’s cell mediated immunity. It stimulate the thymus gland to secrets more T cells and thus increases the cells immunity.
Noni is rich with all major and micronutrients. It is a complete food supplements and provides all the essential nutrients to your body i.e. to your cells. Hence it is a cellular nutrition.
Xeronine, the alkaloid of Noni in the presence of insulin activate the peripheral cell membrane insulin receptors and helps for the normal intracellular absorption of glucose as well as corrects the intracellular post receptor defect of the action of insulin for carbohydrate metabolism and thus prevents the insulin resistance condition in Type – II Diabetes Mellitus condition.Noni works as a ‘Healthy, Immune System Promoter –
Current studies have revealed that Noni may help promote a healthy immune system either by enhancing an already functioning system or by stimulating a sluggish one. Noni activating our body immune system may improve the non functioning beta cells of the pancreas to an active form to produce the normal insulin from the beta cells and also maintain a normal insulin level in the blood to the response of the carbohydrate diet.
Low Glycemic Index –
A 3:1 ratio of carbohydrates to fiber in Noni juice helps balance blood glucose level. With the treatment of diabetic foot ulcer the blood sugar should be within the normal range.
The body immunity power also has a major role in the healing process of diabetes foot ulcer. Noni boosts the body’s cell mediated immunity. It stimulate the thymus gland to secrets more T cells and thus increases the cells immunity.
Noni is rich with all major and micronutrients. It is a complete food supplements and provides all the essential nutrients to your body i.e. to your cells. Hence it is a cellular nutrition.
Noni Scientific Studies
Xeronine and Cell Regeneration
Dr. Ralph Heinicke
As a researcher in Hawaii, Dr. Ralph Heinicke became aware of the marvelous benefits of the Noni fruit and set out to find the pharmacologically active ingredient of the Noni. Dr. Heinicke had spent over 45 years studying the effects of an alkaloid he discovered and named xeronine. Xeronine is a relatively small alkaloid which is physiologically very active and important for the proper functioning of all cells in the body. In his research, Dr. Heinicke discovered that the Noni juice contains appreciable amounts of the precursor of xeronine that he named "pro-xeronine". Pro-xeronine releases pure xeronine in the intestines when it comes in contact with a particular enzyme also found in the Noni Juice.
Dr. Heinicke's theory is that, when released, xeronine actually works at the molecular level to repair damaged cells. Dr. Heinicke states that the primary function of xeronine is to regulate the rigidity and shape of specific proteins. Since these proteins have different functions within the cells, this explains how the administration of Noni Juice causes an unbelievably wide range of physiological responses.
"Some of the problems which drinking Noni Juice might favorably affect are: high blood pressure, menstrual cramps, arthritis, gastric ulcers, sprains, injuries, mental depression, senility, poor digestion, atherosclerosis, blood vessel problems, drug addiction, pain, and many others. Although this list looks like a page torn out of a traveling medicine man's manual, it is probably conservative."
-Dr. Heinicke.
-Dr. Heinicke.
When Ralph M. Heinicke received his doctorate in biochemistry from the University of Minnesota, he wanted to escape from those cold Minnesota winters and so he took a job with Dole Pineapple Company in Hawaii. His first assignment was to develop a method to extract the enzyme that caused pineapple to prevent gelatin deserts from setting up. He found it was an enzyme called bromelain and in due time he and his coworkers found a way to extract it. Soon the Dole Company found that every day they had over a thousand pounds of this crude bromelain enzyme extract left over as a waste product. At the time it had no commercial value, and so the company president asked Dr. Heinicke to see if he could find some use for this material. Eventually he found it was a proteolytic enzyme that had some medical applications. He worked with Smith-Kline and the Rohr pharmaceutical companies to expand its medical use.
In order to get FDA approval for this enzyme he had to refine the crude bromelain extract down to an extremely pure protease enzyme. Much to his and the drug companies amazement, the more pure the enzyme became, the less beneficial it was in many of its applications. Eventually, in its purest state, it had only 5% of its original potency for many of its uses. Dr. Heinicke was then asked to find what it was they were removing, that had given the crude bromelain extract all of its power. Meanwhile, the giant Japanese drug company Toshiba had also launched a 3 year, 3 million dollar program, to find the same answer. At the end of that time they had used up all their money and not found the answer. Not one to give up easily, Dr. Heinicke continued his research and eventually found to his great surprise that the active ingredient was not a protein, carbohydrate or fat, but a substance known as an alkaloid.
Alkaloids are one of the most important classes of phytochemicals known, and a major source from which many modern medicines are drawn. By isolating this alkaloid into a pure state, he was able to identify its exact chemical structure. Because it could be reduced to a dry crystalline structure he decided to use the latin prefix "Xero" meaning "dry" as the first part of its name. Since it was also an alkaline compound, he tacked on the suffix "ine", indicating its alkaline nature. This gives us the word "xeronine", which means "a dry alkaline compound".
Eventually he found that xeronine was a very important biochemical in the human body and essential for good health. The human body has a limited ability to manufacture xeronine from the raw material found in certain fruits. Like with many other biochemicals produced in the body, he found that positive thoughts and emotions, along with exposure to art, music, nature and spiritual experiences, increased its production. While negative thoughts, emotions and stressful experiences suppressed its production. He also learned that as the body's level of xeronine declined with age, stress and a poor diet, the level of health and recovery declined right along with it.
Proving The Essential Nature Of xeronine
Being a scientist, Dr. Heinicke knew that he would have to find a way to prove the essential nature of this amazing alkaloid before he or anyone else could really believe this was essential to good health. During the course of his research through the scientific literature for compounds similar to xeronine, he located one that had a chemical structure that was extremely close.
This chemical cousin is called tetrodotoxin and is the most potent neurotoxic poison known to man. It is a potent alkaloid found in the Puffer Fish. When Dr. Heinicke discovered this fact he realized that here was a way to determine for sure whether the xeronine he had isolated from the pineapple was essential to human health or not. You see, the only reason the body takes up certain toxic chemical substances is because they chemically mimic one the body must normally have. For example, morphine is addictive to the brain only because it chemically mimics natural chemicals of the brain called endorphines and are taken up by the same receptors in the brain. Realizing this Dr. Heinicke reasoned that tetrodotoxin must mimic xeronine. If this were true, Dr. Heinicke realized that the presence of xeronine in the tissues would block the uptake of the poisonous tetrodotoxin and prevent its lethal effect.
An Important Groundbreaking Experiment!
In a groundbreaking experiment Dr. Heinicke proved the tetrodotoxin is accepted by the body only when xeronine was missing. He did this by taking 30 laboratory mice and dividing them into 3 groups of 10 each. He gave an injection of the tetrodotoxin to one group and they all immediately died. Next he gave an injection of an equivalent amount of xeronine to the second group and of course they all lived. Finally he mixed together the amounts of tetrodotoxin and xeronine he had used with the other 2 groups of mice and injected the third group of mice. Not only did all 10 of these mice live, but unlike mice would normally do who have received an intestinal injection, they did not curl up in the wood shavings to recover when placed back in their cages. Instead these mice were alert, energetic, curious and active. Yet these mice had justreceived a lethal dose of the most powerful neurotoxin known to man. This experiment had proven that xeronine is an essential biochemical of good health, and a natural constituent of the body. Because of this, xeronine had been preferentially taken up by the nerve tissue, totally blocking out the highly poisonous tetrodotoxin, and provided not only protection, but exceptionally good health and vigor as well.
In order to get FDA approval for this enzyme he had to refine the crude bromelain extract down to an extremely pure protease enzyme. Much to his and the drug companies amazement, the more pure the enzyme became, the less beneficial it was in many of its applications. Eventually, in its purest state, it had only 5% of its original potency for many of its uses. Dr. Heinicke was then asked to find what it was they were removing, that had given the crude bromelain extract all of its power. Meanwhile, the giant Japanese drug company Toshiba had also launched a 3 year, 3 million dollar program, to find the same answer. At the end of that time they had used up all their money and not found the answer. Not one to give up easily, Dr. Heinicke continued his research and eventually found to his great surprise that the active ingredient was not a protein, carbohydrate or fat, but a substance known as an alkaloid.
Alkaloids are one of the most important classes of phytochemicals known, and a major source from which many modern medicines are drawn. By isolating this alkaloid into a pure state, he was able to identify its exact chemical structure. Because it could be reduced to a dry crystalline structure he decided to use the latin prefix "Xero" meaning "dry" as the first part of its name. Since it was also an alkaline compound, he tacked on the suffix "ine", indicating its alkaline nature. This gives us the word "xeronine", which means "a dry alkaline compound".
Eventually he found that xeronine was a very important biochemical in the human body and essential for good health. The human body has a limited ability to manufacture xeronine from the raw material found in certain fruits. Like with many other biochemicals produced in the body, he found that positive thoughts and emotions, along with exposure to art, music, nature and spiritual experiences, increased its production. While negative thoughts, emotions and stressful experiences suppressed its production. He also learned that as the body's level of xeronine declined with age, stress and a poor diet, the level of health and recovery declined right along with it.
Proving The Essential Nature Of xeronine
Being a scientist, Dr. Heinicke knew that he would have to find a way to prove the essential nature of this amazing alkaloid before he or anyone else could really believe this was essential to good health. During the course of his research through the scientific literature for compounds similar to xeronine, he located one that had a chemical structure that was extremely close.
This chemical cousin is called tetrodotoxin and is the most potent neurotoxic poison known to man. It is a potent alkaloid found in the Puffer Fish. When Dr. Heinicke discovered this fact he realized that here was a way to determine for sure whether the xeronine he had isolated from the pineapple was essential to human health or not. You see, the only reason the body takes up certain toxic chemical substances is because they chemically mimic one the body must normally have. For example, morphine is addictive to the brain only because it chemically mimics natural chemicals of the brain called endorphines and are taken up by the same receptors in the brain. Realizing this Dr. Heinicke reasoned that tetrodotoxin must mimic xeronine. If this were true, Dr. Heinicke realized that the presence of xeronine in the tissues would block the uptake of the poisonous tetrodotoxin and prevent its lethal effect.
An Important Groundbreaking Experiment!
In a groundbreaking experiment Dr. Heinicke proved the tetrodotoxin is accepted by the body only when xeronine was missing. He did this by taking 30 laboratory mice and dividing them into 3 groups of 10 each. He gave an injection of the tetrodotoxin to one group and they all immediately died. Next he gave an injection of an equivalent amount of xeronine to the second group and of course they all lived. Finally he mixed together the amounts of tetrodotoxin and xeronine he had used with the other 2 groups of mice and injected the third group of mice. Not only did all 10 of these mice live, but unlike mice would normally do who have received an intestinal injection, they did not curl up in the wood shavings to recover when placed back in their cages. Instead these mice were alert, energetic, curious and active. Yet these mice had justreceived a lethal dose of the most powerful neurotoxin known to man. This experiment had proven that xeronine is an essential biochemical of good health, and a natural constituent of the body. Because of this, xeronine had been preferentially taken up by the nerve tissue, totally blocking out the highly poisonous tetrodotoxin, and provided not only protection, but exceptionally good health and vigor as well.
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