Scientists only recently have discovered that there are actually two COX enzymes: COX-1 and COX-2. Research shows that in the body, the COX-2 enzyme is largely responsible for causing pain and inflammation. Injury, disease, and trauma cause COX-2 enzymes to produce prosta-glandins, which cause pain and inflammation. In contrast to the COX-2 enzyme, the COX-1 enzyme is responsible for protecting the body’s stomach lining and kidneys. COX-1 enzymes continually produce protective prosta-glandins.
When taken over long period of time, traditional medication for chronic pain and inflammation by way of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) like Aspirin and Ibuprofen, inhibit the enzymatic activity of both COX-1 and COX-2. This inhibition of the COX-2 enzyme reduces the prostaglandins that cause pain and inflammation throughout the body, but over time, it also restrains the COX-1 enzyme from producing the prostaglandins that protect the stomach lining. This can result in major problems, such as ulcers and colitis, in the body’s digestive system.
The discovery of COX-2 created a frenzy in the pharmaceutical world- everyone wanted to find a substance that would inhibit COX-2 without harming the body’s production of COX-1. Exciting scientific findings from carefully conducted research done in an independent laboratory show that Noni selectively inhibits the COX-2 enzyme while allowing the COX-1 enzyme to continue functioning. Some scientists believe that a selective COX-2 inhibitor could help with menstrual pain and help prevent cancers of the colon, esophagus, skin, and bladder. Even those who have been diagnosed with Alzheimer’s may benefit from a selective COX-2 inhibitor.
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